Infantile dermatoses encompass transient or chronic skin conditions in infants under 12 months, where diagnostic complexity arises from remarkably similar presentations of erythema, scaling, and vesicular lesions across etiologically distinct disorders. Key "look-alike" conditions include seborrheic dermatitis (with greasy scales on scalp/face), atopic dermatitis (pruritic, lichenified plaques), candidal intertrigo (sharp-bordered erythema in moist folds), and viral exanthems (e.g., erythema toxicum neonatorum), necessitating meticulous differentiation through age-specific criteria such as lesion distribution, evolution timeline, and associated systemic signs. Diagnostic strategies prioritize non-invasive approaches: detailed maternal/prenatal history, Wood's lamp examination to detect fungal elements, and skin scraping for microscopic analysis, while avoiding premature steroid application that may exacerbate infectious causes. Accurate distinction directly prevents iatrogenic harm, optimizes age-appropriate therapy (e.g., antifungals versus emollients), and reduces parental distress, ultimately safeguarding skin barrier integrity and neurodevelopmental outcomes in this immunologically fragile population.